I found an intregging artical regaurding how nuerons "know" where to migrate to. The article is titled Do neurons in the vertibrate CNS migrate on laminin. Neurons connect to glical cells using a glycoprotein (specificly the glycoprotein laminin) to direct neural migration. The authors used the brains of rat embryos to test limiting the amount of laminin to determine if it did or didnot affect the migration of neurons in the growing brain. After the use of anti-laminin antibodies, "pockets" of laminin were found near radial glial fibers. This provides evidence that this link between the laminin and the radial glial fibers (which provide a pathway for neuron migration) is somehow needed in order govern the role of glial fibers and the migration of neurons. I found this article to be somewhat helpful but it is still unclear as to how exactly neurons migrate.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC554319/pdf/emboj00270-0085.pdf
I'm just a stroke-addled survivor but you can look at this article to find this statement on neurogenesis:
ReplyDeleteInterestingly, the newborn cells differentiated into striatal neurons and acquired the same phenotype of the neurons which had died as a consequence of the stroke, suggesting that neuronal replacement can occur in the stroked striatum (Arvidsson et al., 2002).
https://admin.frontiersin.org/neurogenesis/10.3389/fnins.2011.00047/full
Could be extremely important for stroke survivors, if only we could get phase II and III studies